Treatment of hypophosphataemic vitamin D - resistant rickets with massive doses of 1 a . - hydroxy - vitamin D 3 during childhood
نویسندگان
چکیده
Plasma levels of 1,25 dihydroxy-vitamin D (1,25-(OH)2-D) were low in 3 children with hypophosphataemic vitamin D-resistant rickets (HVDRR) during childhood, but increased after very large doses (0 * 5 to 2 ,g/kg per day) of 1 ao-hydroxy-vitamin D (1 ac-OH-D3). This treatment has two advantages. Firstly, hypercalcaemia is easily controlled by reducing the dose of oc-OH-D3 because of its short half-life. Secondly, the administration of 1 ac-OH-D3 to patients with HVDRR
منابع مشابه
Treatment of hypophosphataemic vitamin D-resistant rickets with massive doses of 1 alpha-hydroxy-vitamin D3 during childhood.
Plasma levels of 1,25 dihydroxy-vitamin D (1,25-(OH)2-D) were low in 3 children with hypophosphataemic vitamin D-resistant rickets (HVDRR) during childhood, but increased after very large doses (0.5 to 2 micrograms/kg per day) of 1 alpha-hydroxy-vitamin D (1 alpha-OH-D3). This treatment has two advantages. Firstly, hypercalcaemia is easily controlled by reducing the dose of 1 alpha-OH-D3 becaus...
متن کاملReport of a Case of Vitamin D Resitant Rickets Associated with Congenital Alopecia
Vitamin D resistant rickets with alopecia is a rather rare heritable disease probably caused by a different variety of metabolic disorder of this vitamin. Disturbances of protoplasmic and unclear receptors for vitamin D metabolites in bones and intestinal cells have been proposed as basic mechanism; Alopecia is attributed to hypersensitivity to vitamin D; very much like what usually appears in ...
متن کاملCongenital Rickets: Report of Four Cases
Introduction: Vitamin D deficiency and rickets continue to be health problems in developing countries and most of the infants with congenital rickets may present with hypocalcemic seizure. Case Report: In this article, the report on four infants who presented with hypocalcemic seizures but subsequently were found to have congenital rickets is presented. All of them had hypocalcaemia and low l...
متن کاملSurvey of Patients with Different Types of Rickets in Fars Province
ABSTRACT There are different causes for rickets. Vitamin D deficiency, disorder in vitamin D metabolism and action, familial x.linked hypophosphatemia, renal failure, hepatic disease & oncogenous rickets are some of the major causes of rickets. In this research we had the opportunity to study 50 cases of rickets during one year period in shiraz. The results showed that vitamin D deficiency wa...
متن کاملCongenital Rickets: Report of Four Cases
Introduction: Vitamin D deficiency and rickets continue to be health problems in developing countries and most of the infants with congenital rickets may present with hypocalcemic seizure. Case Report In this article, the report on four infants who presented with hypocalcemic seizures but subsequently were found to have congenital rickets is presented. All of them had hypocalcaemia and low le...
متن کامل